synthesis and biological evaluation of novel piperazine containing hydrazone derivatives
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2016
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Abstract
Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N′-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin-1-yl]acetohydrazide with aromatic aldehydes. The chemical structures of the compounds were enlightened by FT-IR, 1H-NMR, 13C-NMR, and HRMS (ESI) spectral data. The inhibition potency of the compounds 3a–k against AChE and BuChE was measured and evaluated using a modification of Ellman’s spectrophotometric method. Among the tested compounds, compound 3c was assigned to be the most active derivative. Galantamine was used as a standard drug.
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kaya2016journalsynthesis
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| Authors | ;Betül Kaya;Yusuf Özkay;Halide Edip Temel;Zafer Asım Kaplancıklı |
| Journal | british journal of psychology (london, england : 1953) |
| Year | 2016 |
| DOI |
10.1155/2016/5878410
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