linear density analysis of bone repair in rats using digital direct radiograph análise de densidade linear para reparo ósseo em ratos utilizando radiografia digital direta

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ID: 221913
2004
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Abstract
The objective of this study was to assess bone density measurements for analysis of repairing fractures in rats using direct digital radiography under Dexamethasone effects. Thirty (30) young adult male Wistar rats were used, with an average weight of 200g, which were submitted to general anesthetics by ethyl ether. One rib of each animal was fractured by surgical technique. The rats were divided into 2 groups, named Control group - intraperitoneal administration of saline solution 1 hour prior to operation, and Group 1: intraperitoneal administration of Dexamethasone 0.1mg/Kg of weight 1 hour prior to operation, and two postoperative doses every 12 hours. The animals were sacrificed at 2, 3, 4, 7 and 14 days. The parts containing the hemi-thorax with the fractured rib were removed and submitted to direct digital radiography, where the linear density of the two extremities of the fracture were analyzed by the Digora System. The results showed that in the control group and in Group 1 there was a gradual and significant increase in linear density. The method used made it feasible to supply data that were statistically significant in assessing the gain in bone density during the period of time analyzed. In conclusion, direct digital radiograph is useful for bone density analysis for fracture repairing. The dose of Dexamethasone was not sufficient to alter the gain in bone density at the extremities of fracture.
O objetivo deste estudo foi analisar densidade linear utilizando o sistema de radiografia digital direta intrabucal para verificar o ganho de densidade óssea em fraturas de ratos sob os efeitos da Dexametasona. Trinta (30) ratos Wistar machos, adultos jóvens de 200 g em média foram usados. Os animais foram submetidos á anestesia geral por inalação de éter etílico e 01 costela de cada animal foi fraturada através de técnica cirúrgica. Os ratos foram divididos em grupos de 03 repetições para cada grupo em cada período de tempo: Grupo Controle: administração intraperitoneal de soro fisiológico 01 hora antes da intervenção cirúrugica. Grupo 1: administração intraperitoneal de Dexametasona 0.1mg/Kg de peso 01 hora antes da intervenção e duas doses pós operatórias a cada 12 horas. Os animais foram sacrificados com 02, 03, 04, 07 e 14 dias. As partes contendo o hemi tórax da costela com a fratura foram removidas e submetidas aos raios x, onde as imagens foram analisadas através do sistema Digora. Os resultados mostraram que no grupo Controle e no Grupo 1 houve um ganho gradual na densidade linear. O método utilizado para análise forneceu dados estatisticamente significativos durante o período de tempo analisado. Assim concluimos que o método de radiografia dentária digital pode ser utilizado para análise de densidade linear de fraturas. As doses utilizadas de Dexametasona neste experimento não foram suficientes para alterar a densidade óssea no reparo de fraturas em ratos.
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bozzo2004journallinear Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ricardo de Oliveira Bozzo;Rodney Garcia Rocha;Francisco Haiter Neto;Gisela André Paganini;Marcelo Gusmão Paraiso Cavalcanti
Journal journal of animal and plant sciences
Year 2004
DOI
10.1590/S1678-77572004000400012
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572004000400012
Keywords
dexamethasone densitometry digitaldentistry

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