the immunomodulator vaca promotes immune tolerance and persistent helicobacter pylori infection through its activities on t-cells and antigen-presenting cells

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ID: 221653
2016
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Abstract
VacA is a pore-forming toxin that has long been known to induce vacuolization in gastric epithelial cells and to be linked to gastric disorders caused by H. pylori infection. Its role as a major colonization and persistence determinant of H. pylori is less well-understood. The purpose of this review is to discuss the various target cell types of VacA and its mechanism of action; specifically, we focus on the evidence showing that VacA targets myeloid cells and T-cells to directly and indirectly prevent H. pylori-specific T-cell responses and immune control of the infection. In particular, the ability of VacA-proficient H. pylori to skew T-cell responses towards regulatory T-cells and the effects of Tregs on H. pylori chronicity are highlighted. The by-stander effects of VacA-driven immunomodulation on extragastric diseases are discussed as well.
Reference Key
djekic2016toxinsthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Aleksandra Djekic;Anne Müller
Journal matec web of conferences
Year 2016
DOI
10.3390/toxins8060187
URL
http://www.mdpi.com/2072-6651/8/6/187
Keywords
myeloid cells

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