design, synthesis, and in vitro antioxidant activity of 1,3,5-trisubstituted-2-pyrazolines derivatives
Clicks: 120
ID: 221589
2013
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Abstract
Mannich base of pyrazolines 3(a–e) under both conventional and microwave irradiation was synthesized. All the synthesised compounds were purified
by recrystallisation, characterized on the basis of UV, IR, and NMR spectroscopy, and further supported by mass spectroscopy. The result obtained confirms superiority of
microwave irradiation method over classical heating one. The molecular properties and Lipinski rule of five for compounds 3(a–e) were determined by Molinspiration.
The synthesized compounds were subsequently evaluated for the antioxidant activity. All the compounds were found in compliance with Lipinski “Rule of Five”,
and compound 3e having p-hydroxyl substitution showed best antioxidant activity as compared to ascorbic acid and rutin.
| Reference Key |
jagadish2013journaldesign,
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| Authors | ;P. C. Jagadish;Neeraj Soni;Amita Verma |
| Journal | british journal of psychology (london, england : 1953) |
| Year | 2013 |
| DOI |
10.1155/2013/765768
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