molecular analysis of the interaction of the snake venom rhodocytin with the platelet receptor clec-2

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ID: 221501
2011
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Abstract
The Malayan pit viper, Calloselasma rhodostoma, produces a potent venom toxin, rhodocytin (aggretin) which causes platelet aggregation. Rhodocytin is a ligand for the receptor CLEC-2 on the surface of platelets. The interaction of these two molecules initiates a signaling pathway which results in platelet activation and aggregation. We have previously solved the crystal structures of CLEC-2 and of rhodocytin, and have proposed models by which tetrameric rhodocytin may interact with either two monomers of CLEC-2, or with one or two copies of dimeric CLEC-2. In the current study we use a range of approaches to analyze the molecular interfaces and dynamics involved in the models of the interaction of rhodocytin with either one or two copies of dimeric CLEC-2, and their implications for clustering of CLEC-2 on the platelet surface.
Reference Key
ocallaghan2011toxinsmolecular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Christopher A. O’Callaghan;Aleksandra A. Watson
Journal matec web of conferences
Year 2011
DOI
10.3390/toxins3080991
URL
http://www.mdpi.com/2072-6651/3/8/991/
Keywords
platelets clec-2

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