hypothalamic neurohormones and immune responses

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ID: 220878
2013
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Abstract
The aim of this review is to provide a comprehensive examination of the current literature describing the neural-immune interactions, with emphasis on the most recent findings of the effects of neurohormones on immune system. Particularly, the role of hypothalamic hormones such as Thyrotropin-releasing hormone, Corticotropin-releasing hormone and Gonadotropin-releasing hormone. In the past few years, interest has been raised in extrapituitary actions of these neurohormones due to their receptors have been found in many non-pituitary tissues. Also, the receptors are present in immune cells, suggesting an autocrine or paracrine role within the immune system. In general, these neurohormones have been reported to exert immunomodulatory effects on cell proliferation, immune mediators release and cell function. The implications of these findings in understanding the network of hypothalamic neuropeptides and immune system are discussed.
Reference Key
equintanar2013frontiershypothalamic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;J. Luis eQuintanar;Irene eGuzmán-Soto
Journal drug research
Year 2013
DOI
10.3389/fnint.2013.00056
URL
http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00056/full
Keywords
immune system crf crh receptors gnrh diseases of the nervous system neuropsychiatryneurology biological psychiatry

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