sibling srna ryfa1 influences shigella dysenteriae pathogenesis

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ID: 220321
2017
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Abstract
Small regulatory RNAs (sRNAs) of Shigella dysenteriae and other pathogens are vital for the regulation of virulence-associated genes and processes. Here, we characterize RyfA1, one member of a sibling pair of sRNAs produced by S. dysenteriae. Unlike its nearly identical sibling molecule, RyfA2, predicted to be encoded almost exclusively by non-pathogenic species, the presence of a gene encoding RyfA1, or a RyfA1-like molecule, is strongly correlated with virulence in a variety of enteropathogens. In S. dysenteriae, the overproduction of RyfA1 negatively impacts the virulence-associated process of cell-to-cell spread as well as the expression of ompC, a gene encoding a major outer membrane protein important for the pathogenesis of Shigella. Interestingly, the production of RyfA1 is controlled by a second sRNA, here termed RyfB1, the first incidence of one regulatory small RNA controlling another in S. dysenteriae or any Shigella species.
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fris2017genessibling srna ryfa1 influences shigella dysenteriae Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Megan E. Fris;William H. Broach;Sarah E. Klim;Peter W. Coschigano;Ronan K. Carroll;Clayton C. Caswell;Erin R. Murphy
Journal thermal science and engineering progress
Year 2017
DOI
10.3390/genes8020050
URL
http://www.mdpi.com/2073-4425/8/2/50
Keywords
pathogenesis sibling shigella ompcgenetics

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