role of rankl-rank/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications

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ID: 219727
2011
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Abstract
Bone remodeling is a cyclic and continuous physiological process, which ensures the conservation and renewal of the bone matrix. Osteosynthesis of the bone matrix is achieved by osteoblasts and coordinated within this complex machinery of bone remodeling with resorption of extracellular bone matrix performed by osteoclasts. The mismatch between the activities of osteoblasts and osteoclasts has immunopathologic implications associated with either a decrease or increase of bone mass mineral density. The balance of the trimolecular control factor complex composed of osteoprotegerin (OPG), RANKL (osteoprotegerin ligand) and RANK maintains physiologic bone remodeling. This trimolecular complex functions as receptors and ligands and belongs to the superfamily of tumor necrosis factor (TNF). This mini review highlights the complex interplay of the RANKL-RANK/OPG axis and their immunopathologic implications in clinical medicine.
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kohli2011indianrole Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sarvraj Singh Kohli;Virinder Singh Kohli
Journal journal of physical chemistry a
Year 2011
DOI
10.4103/2230-8210.83401
URL
http://www.ijem.in/article.asp?issn=2230-8210;year=2011;volume=15;issue=3;spage=175;epage=181;aulast=Kohli
Keywords
bone metabolism bone remodeling Gastroenterology clinical endocrinologydiseases of the digestive system

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