chapter 1. immunogenetics: genome wide association of non-progressive hiv and viral load control: hla genes and beyond

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2013
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Abstract
Very early after the identification of the human immunodeficiency virus (HIV), host genetics factors were anticipated to play a role in viral control and disease progression. As early as the mid-1990’s, candidate gene studies demonstrated a central role for the chemokine co-receptor/ligand (e.g. CCR5) and Human Leukocyte Antigen (HLA) systems. In the last decade, the advent of genome-wide arrays opened a new era for unbiased genetic exploration of the genome and brought big expectations for the identification of new unexpected genes and pathways involved in HIV/AIDS. More than fifteen genome-wide association studies (GWAS) targeting various HIV-linked phenotypes have been published since 2007. Surprisingly, only the two HIV-chemokine co-receptors and HLA loci have exhibited consistent and reproducible statistically significant genetic associations. In this chapter, we will review the findings from the genome-wide studies focusing especially on non-progressive and HIV control phenotypes, and discuss the current perspectives.
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elimou2013frontierschapter Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sophie eLimou, Jean Francois eZagury
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Journal sudebno-meditsinskaia ekspertiza
Year 2013
DOI
10.3389/fimmu.2013.00118
URL
http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00118/full
Keywords
hiv-1 snp genome-wide association study (gwas) hla allergy

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