inhibition of germinal centre apoptotic programmes by epstein-barr virus

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ID: 219096
2011
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Abstract
To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the virus-infected host cell must transit through the germinal centre reaction. This is a site of B cell differentiation where antibody responses are optimised, and the selection criteria for B cells are stringent. The germinal centre environment is harsh, and the vast majority of B cells here die by apoptosis. Only cells receiving adequate survival signals will differentiate fully to be released into the periphery as long-term memory B cells (the site of persistence). In this review, we detail the apoptotic pathways potentially encountered by EBV-infected B cells during the process of infection, and we describe the functions of those EBV-regulated cellular and viral genes that help promote survival of the host B cell.
Reference Key
spender2011advancesinhibition Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Lindsay C. Spender;Gareth J. Inman
Journal the european journal of general practice
Year 2011
DOI
10.1155/2011/829525
URL
http://dx.doi.org/10.1155/2011/829525
Keywords
Diseases of the blood and blood-forming organs

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