the reliability of repeated tms measures in older adults and in patients with subacute and chronic stroke

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ID: 217801
2015
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Abstract
The reliability of transcranial magnetic stimulation (TMS) measures in healthy older adults and stroke patients has been insufficiently characterized. We determined whether common TMS measures could reliably evaluate change in individuals and in groups using the smallest detectable change (SDC), or could tell subjects apart using the intraclass correlation coefficient (ICC). We used a single-rater test-retest design in older healthy, subacute stroke, and chronic stroke subjects. At twice daily sessions on two consecutive days, we recorded resting motor threshold, test stimulus intensity, recruitment curves, short-interval intracortical inhibition and facilitation, and long-interval intracortical inhibition. Using variances estimated from a random effects model, we calculated the SDC and ICC for each TMS measure. For all TMS measures in all groups, SDCs for single subjects were large; only with modest group sizes did the SDCs become low. Thus, while these TMS measures cannot be reliably used as a biomarker to detect individual change, they can reliably detect change exceeding measurement noise in moderate-sized groups. For several of the TMS measures, ICCs were universally high, suggesting that they can reliably discriminate between subjects. Though most TMS measures have sufficient reliability in particular contexts, work establishing their validity, responsiveness, and clinical relevance is still needed.
Reference Key
schambra2015frontiersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Heidi M. Schambra;R. Todd eOgden;Isis eMartínez-Hernández;Xuejing eLin;Y. Brenda eChang;Asif eRahman;Dylan eEdwards;John W. Krakauer
Journal macromolecular bioscience
Year 2015
DOI
10.3389/fncel.2015.00335
URL
http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00335/full
Keywords
Biomarker reliability icc measurement error tms neuropsychiatry biological psychiatry

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