transcriptional profiling of c. albicans in a two species biofilm with rothia dentocariosa

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ID: 217364
2017
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Abstract
Biofilms on silicone rubber voice prostheses are the major cause for frequent failure and replacement of these devices. The presence of both bacterial and yeast strains has been suggested to be crucial for the development of voice prosthetic biofilms. Polymicrobial biofilms that include Candida albicans and Rothia dentocariosa are the leading cause of voice prosthesis failure. An in vitro biofilm comprising these two organisms was developed on silicone rubber, a material used for Groningen button voice prosthesis. We found that this biofilm environment was not conducive for C. albicans growth or differentiation. Global transcriptional analyses of C. albicans biofilm cells grown with R. dentocariosa revealed that genes with functions related to cell cycle progression and hyphal development were repressed >2-fold. The mixed species biofilms were more compact and less robust compared to C. albicans mono-species biofilms, even when developed under conditions of continuous nutrient flow. Under these conditions R. dentocariosa also significantly inhibited C. albicans biofilm dispersal. Preferential adherence of R. dentocariosa to candidal hyphae was mediated by the adhesin Als3.
Reference Key
uppuluri2017frontierstranscriptional Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Priya Uppuluri;Henk J. Busscher;Jaideep Chakladar;Henny C. van der Mei;W. LaJean Chaffin
Journal electronic physician
Year 2017
DOI
10.3389/fcimb.2017.00311
URL
http://journal.frontiersin.org/article/10.3389/fcimb.2017.00311/full
Keywords
biofilm candida albicans

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