emerging neurotrophic role of gabab receptors in neuronal circuit development
Clicks: 172
ID: 217298
2013
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Steady Performance
30.0
/100
171 views
17 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
The proper development of highly organized structures in the central nervous system is a complex process during which key events – neurogenesis, migration, growth, differentiation and synaptogenesis – have to take place in an appropriate manner to create functional neuronal networks. It is now well established that GABA, the main inhibitory neurotransmitter in the mammalian brain, plays more than a classical inhibitory role and can function as an important developmental signal early in life. GABA binds to chloride-permeable ionotropic GABAA receptors and to G-protein-coupled GABAB receptors. Although most of the trophic actions of GABA have been attributed to the activation of GABAA receptors, recent advances show that GABAB receptors also regulate fundamental steps of network development. This review summarizes some of the recent progress about the neurotrophic role of GABAB receptors to neuronal development.
| Reference Key |
egaiarsa2013frontiersemerging
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Jean-Luc eGaiarsa;Jean-Luc eGaiarsa;Christophe ePorcher;Christophe ePorcher |
| Journal | macromolecular bioscience |
| Year | 2013 |
| DOI |
10.3389/fncel.2013.00206
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.