avaliação da agregação plaquetária e dosagem do fibrinogênio em pacientes com doenças cardiovasculares e sua correlação com o uso de aspirina e fatores de risco coronariano evaluation of platelet aggregation and level of fibrinogen in patients with cardiovascular diseases and the correlation of taking aspirin with coronary risk factors
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Abstract
OBJECTIVE: To evaluate aspirin resistance in patients with cardiovascular diseases and to compare the amount of serum fibrinogen in patients taking aspirin with those who do not. To correlate the platelet aggregation and serum fibrinogen to cardiovascular risk parameters. METHODS: Eighty-two patients were divided into two groups: Group 1 - 41 patients who took 100mg aspirin daily and Group 2 - 41 patients who did not utilized platelet antiaggregates. Epidemiological data were collected including age, gender and information on smoking and alcohol intake and serum fibrinogen and platelet aggregation were mesured. RESULTS: In the groups analyzed, advanced age (p=0.011), smoking (p=0.009) and alcoholism (p=0.007) were directly associated to the serum fibrinogenen level. There were no correlations between smoking, alcoholism, serum fibrinogen and platelet aggregation values (p>0.05). In Group 1, 29% of the patients presented with aspirin resistance. Of these, smokers (p=0.029) and the alcoholics (p=0.033) had higher serum fibrinogen levels. CONCLUSION: Aspirin resistance was present in a high number of patients. Moreover, advanced age, smoking and alcoholism had a direct influence on the serum fibrinogen levels.
AMAÇ: Kardiyovasküler hastalığı olan hastalarda aspirin direncini değerlendirmek ve aspirin kullanan hastalardaki serum fibrinojen miktarını kullanmayanlarla karşılaştırmak. Trombosit agregasyonunu ve serum fibrinojenini kardiyovasküler risk parametreleri ile ilişkilendirmek. YÖNTEM: Seksen iki hasta iki gruba ayrıldı: Grup 1 - günde 100 mg aspirin kullanan 41 hasta ve Grup 2 - trombosit antiagreganı kullanmayan 41 hasta. Yaş, cinsiyet ile sigara ve alkol tüketimine ilişkin bilgileri içeren epidemiyolojik veriler toplandı; serum fibrinojeni ve trombosit agregasyonu ölçüldü. BULGULAR: İncelenen gruplarda ileri yaş (p=0,011), sigara kullanımı (p=0,009) ve alkolizm (p=0,007) serum fibrinojen düzeyi ile doğrudan ilişkiliydi. Sigara kullanımı, alkolizm, serum fibrinojeni ve trombosit agregasyon değerleri arasında korelasyon bulunmadı (p>0,05). Grup 1'deki hastaların %29'unda aspirin direnci saptandı. Bunlar arasında sigara içenler (p=0,029) ve alkol kullananlar (p=0,033) daha yüksek serum fibrinojen düzeylerine sahipti. SONUÇ: Aspirin direnci yüksek sayıda hastada mevcuttu. Ayrıca ileri yaş, sigara kullanımı ve alkolizm, serum fibrinojen düzeyleri üzerinde doğrudan bir etkiye sahipti.
| Reference Key |
gabriel2006brazilianavaliao
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| Authors | ;Sthefano Atique Gabriel;Cristiane Knopp Tristão;Luciana Cristante Izar;Carolina Domingues;Edmo Atique Gabriel;Marcelo Gil Cliquet |
| Journal | 2017 international conference on information technology systems and innovation, icitsi 2017 - proceedings |
| Year | 2006 |
| DOI |
10.1590/S0102-76382006000300008
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