sickle cell anemia patients in use of hydroxyurea: association between polymorphisms in genes encoding metabolizing drug enzymes and laboratory parameters
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ID: 216328
2018
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Abstract
This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under hydroxyurea (SCA-HU+). We evaluated hematologic and biochemical parameters by electronic methods and SNPs by PCR-RFLP and multiplex PCR in 35 SCA-HU+ patients and 67 SCA-HU− patients. The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, total bilirubin and fractions levels, and leukocyte, eosinophil, monocyte, and erythroblast counts were reduced in SCA-HU+ patients (p<0.05). Moreover, they presented higher HbF, C-reactive protein, and ferritin levels and elevated MCH and MCV values (p<0.05). Genotype frequencies of variants GA + AA of MPO −463G>A and c1c2 + c2c2 of CYP2E1 −1293G>C/−1053C>T were higher in SCA-HU+ patients (p<0.05). Independent associations were found between the variant A allele and lower total cholesterol, between c2 allele and low alpha-1 antitrypsin and between the null GSTT1 variant and high indirect and total bilirubin in SCA-HU+ patients. In SCA-HU− patients, independent associations were found between the variant A allele and high uric acid and between c2 allele and high urea. Our results suggest that SNPs MPO −463G>A, CYP2E1 −1293G>C/−1053C>T, and GSTT1 can be associated with alterations in lipid, inflammatory, renal, hemolytic, and hepatic profiles. However, further studies are needed to elucidate these associations.
| Reference Key |
yahoudhou2018diseasesickle
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| Authors | ;Sètondji Cocou Modeste Alexandre Yahouédéhou;Magda Oliveira Seixas Carvalho;Rodrigo Mota Oliveira;Rayra Pereira Santiago;Caroline Conceição da Guarda;Suellen Pinheiro Carvalho;Júnia Raquel Dutra Ferreira;Milena Magalhães Aleluia;Elisângela Vitória Adorno;Marilda de Souza Gonçalves |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2018 |
| DOI |
10.1155/2018/6105691
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| URL | |
| Keywords |
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