teratogenic effects of gentamicin on skeletal system of rat fetuses

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ID: 215214
1999
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Abstract
Gentamicin was evaluated for developmental toxicity in pregnant Sprague-Dawley rat. Gentamicin was administered subcutaneously on days 6-15 gestation at dose of 100 mg/kg. On gestation day 21, all live fetuses were examined for external and skeletal malformations and variations. Increased resorptions and dead fetuses, and reduced fetal body weight were observed at dose of 100 mg/kg. Gentamicin caused severe skeletal anomalies, such as: wavy ribs, incomplete ossification of sternebrae, tail vertebra, metacarpus, metatarsus and calvaria. These results indicate the nature and extent of embryotoxicity and teratogenicity of gentamicin in Sprague-Dawley rats.
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h1999tehranteratogenic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marzban H;Akbari M;Toobak M
Journal asian journal of chemistry
Year 1999
DOI
DOI not found
URL
http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5639.pdf&manuscript_id=5639
Keywords
Medicine (General)

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