the escherichia coli hfq protein: an unattended dna-transactions regulator

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ID: 215053
2016
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Abstract
The Hfq protein was discovered in Escherichia coli as a host factor for bacteriophage Qβ RNA replication. Subsequent studies indicated that Hfq is a pleiotropic regulator of bacterial gene expression. The regulatory role of Hfq is ascribed mainly to its function as an RNA-chaperone, facilitating interactions between bacterial noncoding RNA and its mRNA target. Thus, it modulates mRNA translation and stability. Nevertheless, Hfq is able to interact with DNA as well. Its role in the regulation of DNA-related processes has been demonstrated. In this mini-review, it is discussed how Hfq interacts with DNA and what is the role of this protein in regulation of DNA transactions. Particularly, Hfq has been demonstrated to be involved in the control of ColE1 plasmid DNA replication, transposition, and possibly also transcription. Possible mechanisms of these Hfq-mediated regulations are described and discussed.
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cech2016frontiersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Grzegorz M Cech;Agnieszka Szalewska-Pałasz;Krzysztof Kubiak;Antoine Malabirade;Wilfried Grange;Veronique Arluison;Grzegorz Wegrzyn
Journal biopsychosocial medicine
Year 2016
DOI
10.3389/fmolb.2016.00036
URL
http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00036/full
Keywords
dna replication hfq

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