interplay of t helper 17 cells with cd4+cd25high foxp3+ tregs in regulation of allergic asthma in pediatric patients
Clicks: 231
ID: 215050
2014
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
69.1
/100
231 views
186 readers
Trending
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #24 of 79 articles by views in journal of experimental child psychology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Background. There is evidence that Tregs are important to prevent allergic diseases like asthma but limited literature exists on role of TH17 cells in allergic diseases. Methods. Fifty children with asthma and respiratory allergy (study group) and twenty healthy children (control group) were recruited in this study. Total IgE levels and pulmonary function tests were assessed. The expression of Tregs and cytokines was determined by flow cytometry. Results. The average level of total IgE in study group (316.8 ± 189.8 IU/mL) was significantly higher than controls (50 ± 17.5 IU/mL, P<0.0001). The frequency of TH17 cells and culture supernatant level of IL-17 in study group (12.09 ± 8.67 pg/mL) was significantly higher than control group (2.01 ± 1.27 pg/mL, P<0.001). Alternatively, the frequency of FOXP3 level was significantly lower in study group [(49.00 ± 13.47)%] than in control group [(95.91 ± 2.63)%] and CD4+CD25+FOXP3+ to CD4+CD25+ ratio was also significantly decreased in study group [(6.33 ± 2.18)%] compared to control group [(38.61 ± 11.04)%]. The total serum IgE level is negatively correlated with FOXP3 level (r=-0.5273, P<0.0001). The FOXP3 expression is negatively correlated with the IL-17 levels (r=-0.5631, P<0.0001) and IL-4 levels (r=-0.2836, P=0.0460). Conclusions. Imbalance in TH17/Tregs, elevated IL-17, and IL-4 response and downregulation of FOXP3 were associated with allergic asthma.
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (87 words).
Try re-searching for a better abstract.
| Reference Key |
agarwal2014internationalinterplay
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Amit Agarwal;Meenu Singh;B. P. Chatterjee;Anil Chauhan;Anuradha Chakraborti |
| Journal | journal of experimental child psychology |
| Year | 2014 |
| DOI |
10.1155/2014/636238
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.