erythrocyte nanovesicles: biogenesis, biolo
Clicks: 235
ID: 214974
2017
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Abstract
Nanovesicles (NVs) represent a novel transporter for cell signals to modify functions of target cells. Therefore, NVs play many roles in both physiological and pathological processes. This report highlights biogenesis, composition and biological roles of erythrocytes derived nanovesicles (EDNVs). Furthermore, we address utilization of EDNVs as novel drug delivery cargo as well as therapeutic target. EDNVs are lipid bilayer vesicles rich in phospholipids, proteins, lipid raft, and hemoglobin. In vivo EDNVs biogenesis is triggered by an increase of intracellular calcium levels, ATP depletion and under effect of oxidative stress conditions. However, in vitro production of EDNVs can be achieved via hypotonic treatment and extrusion of erythrocyte. NVs can be used as biomarkers for diagnosis, monitoring of therapy and drug delivery system. Many therapeutic agents are suggested to decrease NVs biogenesis.
| Reference Key |
harisa2017saudierythrocyte
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|---|---|
| Authors | ;Gamaleldin I. Harisa;Mohamed M. Badran;Fars K. Alanazi |
| Journal | International journal for quality in health care : journal of the International Society for Quality in Health Care |
| Year | 2017 |
| DOI |
10.1016/j.jsps.2015.06.010
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