diagnosis of sarcoidosis in the endobronchial ultrasound-guided transbronchial needle aspiration era

Clicks: 200
ID: 213928
2014
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #70 of 210 articles by views in the journal of applied psychology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 210 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Background: Sarcoidosis is a multisystemic disorder of unknown etiology. Its diagnosis is based on compatible clinical and radiological features and supported by histological demonstration of epithelioid cell noncaseating granulomas with exclusion of other causes. Endobronchial ultrasound combined with transbronchial needle aspiration (EBUS-TBNA) has been proposed as a valuable tool in obtaining suitable tissue sample.The aim of this study was to evaluate the contribution of EBUS-TBNA to the diagnosis of stages I and II thoracic sarcoidosis in a community-based hospital. Methods: A prospective study was conducted in patients with suspected stages I and II pulmonary sarcoidosis, based on clinical and radiological data, who were being followed in our Interstitial Lung Disorders Outpatient Clinic or sent from other hospitals to our Respiratory Endoscopy Unit for diagnostic procedures. All suitable and fit patients underwent EBUS-TBNA between March 2010 and June 2013.We assessed demographic characteristics, radiological stages, cytological/histological examination and diagnostic techniques performed. Results: In the period considered 39 patients underwent EBUS-TBNA for suspected stages I and II thoracic sarcoidosis and adequate samples were obtained in 38 (97.4%). Within this population, 33 (84.6%) patients had a definite diagnosis of sarcoidosis, of which 31 patients (93.9%) were confirmed to have epithelioid noncaseating granulomas by EBUS-TBNA. Four patients were submitted to surgical procedures (three to mediastinoscopy and one to open surgical lung biopsy).Data analysis allowed to calculate a sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of 93.9%, 100%, 100%, 75.0% and 94.8%, respectively. No complications were observed. Conclusions: EBUS-TBNA is a valuable tool in the diagnostic workup of patients with suspected stages I and II thoracic sarcoidosis providing a substantial number of pathological confirmations and with few complications. Its high diagnostic accuracy precludes the need for more invasive procedures such as surgical biopsy. Resumo: Antecedentes: A Sarcoidose é uma doença multissistémica de etiologia desconhecida. O seu diagnóstico baseia-se em características clínicas e radiológicas compatíveis e é apoiado pela demonstração histológica de granulomas epitelióides não caseosos, com a exclusão de outras causas. A ecoendoscopia brônquica combinada com a punção aspirativa transbrônquica (EBUS-TBNA) foi proposta como uma ferramenta valiosa na obtenção de amostras de tecido adequadas.O objectivo deste estudo foi avaliar o contributo da EBUS-TBNA para o diagnóstico de sarcoidose torácica de estádio I e II num hospital central. Metodologia: Foi realizado um estudo prospectivo em doentes com suspeita de sarcoidose torácica de estádio I e II, com base em dados clínicos e radiológicos, que estavam a ser seguidos na nossa Clínica Ambulatória de Doenças Pulmonares Intersticiais, ou foram enviados de outros hospitais para a nossa Unidade de Endoscopia Respiratória, para os procedimentos de diagnóstico. Todos os doentes adequados e aptos foram submetidos a EBUS-TBNA, entre Março de 2010 e Junho de 2013.Avaliámos as características demográficas, os estádios radiológicos, exames citológicos/histológicos e técnicas de diagnóstico usados. Resultados: No período referido anteriormente, 39 doentes foram submetidos a EBUS-TBNA para a suspeita de sarcoidose torácica de estádio I e II, e foram obtidas amostras adequadas em 38 deles (97,4%). Nesta população, 33 (84,6%) doentes receberam um diagnóstico definitivo de sarcoidose, dos quais 31 doentes (93,9%) foram confirmados como tendo granulomas epitelioides não caseosos, pela EBUS-TBNA. Quatro doentes foram submetidos a procedimentos cirúrgicos (três a mediastinoscopia e outro a biopsia pulmonar cirúrgica aberta).A análise dos dados permitiu calcular uma sensibilidade, especificidade, valor preditivo positivo, valor preditivo negativo e acuidade diagnóstica de 93,9%, 100%, 100%, 75,0% e 94,8%, respectivamente. Não foram observadas complicações. Conclusões: A EBUS-TBNA é uma ferramenta valiosa na abordagem diagnóstica dos doentes com suspeita de sarcoidose torácica de estádio I e II, proporcionando um número importante de confirmações patológicas e com poucas complicações. A sua elevada acuidade diagnóstica exclui a necessidade de procedimentos mais invasivos como uma biópsia cirúrgica. Keywords: Diagnosis, Endobronchial ultrasound-guided transbronchial needle aspiration, Sarcoidosis, Palavras-chave: Diagnóstico, Punção aspirativa transbrônquica guiada por ecoendoscopia brônquica linear, Sarcoidose
Reference Key
ribeiro2014revistadiagnosis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors C. Ribeiro, A. Oliveira, S. Neves, S. Campainha, C. Nogueira, S. Torres, M.C. Brito, J. Almeida, J.M. e Sá
Are you one of these authors? Claim your profile
Journal the journal of applied psychology
Year 2014
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S087321591400035X
Keywords
diseases of the respiratory system

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.