hiv-associated neuromuscular weakness syndrome in brazil: report of the two first cases síndrome da fraqueza neuromuscular associada ao hiv no brasil: relato dos dois primeiros casos

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ID: 213790
2007
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Abstract
We describe two Brazilian patients with HIV-associated neuromuscular weakness syndrome (HANWS), a unique clinical toxic syndrome that was recently reported in developed countries. Both patients were women, used stavudine and had hyperlactatemia, one of them with lactic acidosis. Eletrophysiological studies were consistent with axonal neuropathy. After discontinuation of antiretroviral therapy the patients had significant improvement in neurologic manifestations, and normalization of lactate levels. To our knowledge, this is the first report of HANWS in developing countries. Growing use of antiretroviral therapy in this setting, particularly stavudine, make it likely that similar cases will be observed.
Os autores descrevem dois pacientes brasileiros com a síndrome da fraqueza neuromuscular associada ao HIV, uma síndrome tóxica, clínicamente particular, que foi recentemente relatada em países desenvolvidos. Ambas pacientes eram do sexo feminino, usavam estavudina e apresentaram hiperlactatemia, uma delas com acidose láctica. Os exames electrofisiológicos foram consistentes com neuropatia axonal. As pacientes melhoraram significativamente das alterações neurológicas, assim como normalizaram os níveis de lactato, após descontinuar o uso dos antiretrovirais. Até onde sabemos, este é o primeiro relato da síndrome de fraqueza neuromuscular associada ao HIV em países em desenvolvimento. Nesse contexto, o uso crescente de antiretrovirais, particularmente a estavudina, possibilitarão que casos similares sejam observados.
Reference Key
vidal2007arquivoshiv-associated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;José E. Vidal;David Clifford;Cláudio Meilman Ferreira;Augusto C. Penalva de Oliveira
Journal communications in computer and information science
Year 2007
DOI
10.1590/S0004-282X2007000500024
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500024
Keywords
neuromuscular diseases antiretroviral agents neuropsychiatry biological psychiatry vírus da imunodeficiência humana human immunodeficiency virusneurosciences

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