age-dependent demethylation of sod2 promoter in the mouse femoral artery
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ID: 213613
2016
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Abstract
We studied the age-dependent regulation of the expression of the antioxidant enzyme manganese superoxide dismutase (MnSOD encoded by Sod2) through promoter methylation. C57Bl/6 mice were either (i) sedentary (SED), (ii) treated with the antioxidant catechin (CAT), or (iii) voluntarily exercised (EX) from weaning (1-month old; mo) to 9 mo. Then, all mice aged sedentarily and were untreated until 12 mo. Sod2 promoter methylation was similar in all groups in 9 mo but decreased (p<0.05) in 12 mo SED mice only, which was associated with an increased (p<0.05) transcriptional activity in vitro. At all ages, femoral artery endothelial function was maintained; this was due to an increased (p<0.05) contribution of eNOS-derived NO in 12 mo SED mice only. CAT and EX prevented these changes in age-related endothelial function. Thus, a ROS-dependent epigenetic positive regulation of Sod2 gene expression likely represents a defense mechanism prolonging eNOS function in aging mouse femoral arteries.
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| Reference Key |
nguyen2016oxidativeage-dependent
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|---|---|
| Authors | ;Albert Nguyen;François Leblond;Maya Mamarbachi;Steve Geoffroy;Eric Thorin |
| Journal | journal of aoac international |
| Year | 2016 |
| DOI |
10.1155/2016/8627384
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| URL | |
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