association between angiogenesis soluble factors and disease progression markers in chronic hepatitis c patients asociación entre factores angiogénicos solubles y marcadores de progresión de la enfermedad en pacientes con hepatitis crónica c

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ID: 212924
2005
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Abstract
Objectives: our objectives were to compare angiogenesis soluble factor (ASF) levels in chronic hepatitis C (CHC) patients and healthy individuals, and to investigate potential associations between ASF levels and both histological and biochemical markers of disease progression. Method: thirty-six patients (69% males) positive for HCV-RNA by PCR analysis were included in the study. All patients underwent liver biopsy before treatment. Serum levels of vascular endothelial growth factor (VEGF), soluble Flt-1 and Flk-1 receptors, placental growth factor (PlGF), angiopoietin-2 (Ang-2) and soluble Tie-2 receptor were determined by ELISA. Fifteen healthy subjects were used as controls. Results: in comparison to healthy individuals, CHC patients showed significantly increased serum levels of proangiogenic factors PlGF (22 ± 5 vs. 18 ± 8 pg/ml; p < 0.05), Ang-2 (1265 ± 385 vs. 833 ± 346 pg/ml; p < 0.005) and sFlt-1 (95 ± 22 vs. 72 ± 14 pg/ml; p < 0.0001). Interestingly, in CHC patients serum levels of VEGF and Tie-2 correlated with grade of inflammation, PlGF correlated with stage of fibrosis, and Flt-1 and Flk-1 correlated with serum transaminase levels (p < 0.05 in all cases). Conclusions: CHC patients showed increased serum levels of ASF, and a significant correlation was shown between serum levels of selected ASFs and grade of inflammation, stage of fibrosis, and transaminase levels.
Objetivos: el objetivo fue comparar los niveles de los factores solubles de angiogenesis (FSA) en pacientes con hepatitis crónica C (HCC) con individuos sanos, e investigar la asociación entre los niveles de FSA y los marcadores histológicos y bioquímicos de la enfermedad. Método: treinta y seis pacientes (69,4% hombres) positivos para el ARN-VHC fueron incluidos; a todos se les realizó biopsia hepática antes del tratamiento. Los niveles séricos del factor de crecimiento endotelial vascular (VEGF), de la forma soluble de sus receptores Flt-1 y Flk-1, del factor de crecimiento placentario (PlGF), de la angiopoyetina-2 (Ang-2) y de la forma soluble de su receptor Tie-2 fueron determinados por ELISA. Se analizaron también 15 controles sanos. Resultados: al comparar los pacientes con HCC y los controles se observó una elevación significativa en los niveles de PlGF (22 ± 5 vs. 18 ± 8 pg/ml; p < 0,05), Ang-2 (1265 ± 385 vs. 833 ± 346 pg/ml; p < 0,005) y sFlt-1 (95 ± 22 vs. 72 ± 14 pg/ml; p < 0,0001). Se observó una correlación entre el VEGF y el Tie-2 con el grado de inflamación; entre PlGF y el estadio de la fibrosis; y entre Flt-1 y Flk-1 y los niveles de transaminasas (p < 0,05 en todos los casos). Conclusiones: en pacientes con HCC se observó una elevación significativa de los FSA demostrándose una correlación significativa entre los niveles séricos de ciertos FSA y el grado de inflamación, el estadio de fibrosis y los niveles de transaminasas.
Reference Key
mora2005revistaassociation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;X. Salcedo Mora;P. Sanz-Cameno;J. Medina;S. Martín-Vílchez;L. García-Buey;M. J. Borque;R. Moreno-Otero
Journal chemistry of heterocyclic compounds
Year 2005
DOI
DOI not found
URL
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082005001000003
Keywords
Chronic Hepatitis C fibrosis angiogenesis inflamación Gastroenterology

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