myeloid derived suppressor cells as therapeutic target in hematological malignancies

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ID: 212657
2014
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Abstract
Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that accumulate during pathological conditions such as cancer and are associated with a poor clinical outcome. MDSC expansion hampers the host anti-tumor immune response by inhibition of T cell proliferation, cytokine secretion and recruitment of regulatory T cells. In addition, MDSC exert non-immunological functions including the promotion of angiogenesis, tumor invasion and metastasis. Recent years, MDSC are considered as a potential target in solid tumors and hematological malignancies to enhance the effects of currently used immune modulating agents. This review focuses on the characteristics, distribution, functions, cell-cell interactions and targeting of MDSC in hematological malignancies including multiple myeloma, lymphoma and leukemia.
Reference Key
veirman2014frontiersmyeloid Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kim eDe Veirman;Els eVan Valckenborgh;Qods eLahmar;Qods eLahmar;Xenia eGeeraerts;Xenia eGeeraerts;Elke eDe Bruyne;Eline eMenu;Ivan eVan Riet;Ivan eVan Riet;Karin eVanderkerken;Jo A Van Ginderachter;Jo A Van Ginderachter
Journal international journal of heat and technology
Year 2014
DOI
10.3389/fonc.2014.00349
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00349/full
Keywords
lymphoma leukemia multiple myeloma stem cell transplantation Oncology including cancer and carcinogens tumors

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