evaluation of clinical symptoms of patients with scleroderma according to the onset time1

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2000
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Abstract
Systemic sclerosis is a generalized disorder of connective tissue, in which the pattern of disease extent, progression and outcome is heterogenous. To determine clinical features, disease extent and progression, we studied our patients in two phases of disease; early (the first 3 years) and late phases (after 6 years of disease). 19 patients had diffuse cutaneous and 34 patients had limited cutaneous scleroderma. In patients with diffuse cutaneous scleroderma, disease progression has occurred mostly in the early phase of disease, but in patients with limited cutaneous scleroderma, disease progression was slow and incidious, so disease progression has occurred mostly in the late phase of the disease, thus raynaud's phenomenon, telangiectasia, hyperpigmentation and esophagitis were observed more in the late phase of the disease (statistically significant). In comparison of two groups, early and extensive organ involvement was observed in patients with diffuse cutaneous sclerodema.
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Authors ;Khalvat A;Gharibduost F;Najafizadeh R
Journal asian journal of chemistry
Year 2000
DOI
DOI not found
URL
http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5530.pdf&manuscript_id=5530
Keywords
systemic sclerosis

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