research advances in molecular targeted therapy for advanced biliary tract cancer

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ID: 211576
2014
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Abstract
Molecular targeted therapy has become a new hot spot with the in-depth basic research on advanced biliary tract cancer (ABTC). Phase Ⅱ and Ⅲ trials of the molecular targeted therapies for ABTC are summarized to provide new insights into clinical practice. Phase II trials have shown that vascular endothelial growth factor receptor inhibitor and mitogen-activated protein kinase inhibitor do not exhibit good anti-tumor activity, but epidermal growth factor receptor (EGFR) inhibitor has proven to be safe and effective in the treatment of ABTC. The only multicenter, open-label, randomized, controlled phase Ⅲ trial has shown that nilotinib combined with gemcitabine and oxaliplatin, as the first-line chemotherapy for ABTC, cannot significantly increase the overall survival in patients. Subgroup analysis has shown that standard chemotherapy combined with nilotinib can significantly increase the progression-free survival in patients. These results indicate that EGFR inhibitor is effective to control the progression of ABTC, suggesting that EGFR might be a novel therapeutic target.
Reference Key
mingwu2014linchuangresearch Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;LI Mingwu
Journal lontar komputer
Year 2014
DOI
10.3969/j.issn.1001-5256.2014.11.032
URL
http://www.lcgdbzz.org/qk_content.asp?id=6132&ClassID=101793132
Keywords
Gastroenterology epidermal growth factor; vascular endothelial growth factors; mitogen-activated protein kinases; reviewdiseases of the digestive system

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