critical role for very-long chain sphingolipids in invariant natural killer t cell development and homeostasis

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ID: 211260
2017
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Abstract
The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological processes. The acyl chain length of SLs appears particularly critical in determining SL function. Here, we show a role for very-long acyl chain SLs (VLC-SLs) in invariant natural killer T (iNKT) cell maturation in the thymus and homeostasis in the liver. Ceramide synthase 2-null mice, which lack VLC-SLs, were susceptible to a hepatotropic strain of lymphocytic choriomeningitis virus, which is due to a reduction in the number of iNKT cells. Bone marrow chimera experiments indicated that hematopoietic-derived VLC-SLs are essential for maturation of iNKT cells in the thymus, whereas parenchymal-derived VLC-SLs are crucial for iNKT cell survival and maintenance in the liver. Our findings suggest a critical role for VLC-SL in iNKT cell physiology.
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saroha2017frontierscritical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ashish Saroha;Yael Pewzner-Jung;Natalia S. Ferreira;Piyush Sharma;Youenn Jouan;Samuel L. Kelly;Ester Feldmesser;Alfred H. Merrill;François Trottein;Christophe Paget;Christophe Paget;Karl S. Lang;Anthony H. Futerman
Journal sudebno-meditsinskaia ekspertiza
Year 2017
DOI
10.3389/fimmu.2017.01386
URL
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01386/full
Keywords
lymphocytic choriomeningitis virus allergy glycosphingolipids

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