effects of antibiotic consumption on children 2-8 years of age developing asthma

Clicks: 196
ID: 211254
2014
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Abstract
OBJECTIVES Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age. METHODS A case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic children based on Global Initiative for Asthma criteria (n=207), and the controls were children without respiratory symptoms (n=400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing parents/guardians. RESULTS Antibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symptoms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p<0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p=0.03). CONCLUSIONS Our study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed.
Reference Key
khalkhali2014epidemiologyeffects Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Hamid Reza Khalkhali;Sima Oshnouei;Shaker Salarilak;Mohammadhossein Rahimi Rad;Mohammad Karamyar;Javad Khashabi
Journal fiabilitate şi durabilitate
Year 2014
DOI
10.4178/epih/e2014006
URL
http://www.e-epih.org/upload/pdf/epih-36-e2014006.pdf
Keywords
childhood asthma antibiotic use

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