russell body gastroenteritis: an aberrant manifestation of chronic inflammation in gastrointestinal mucosa

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ID: 210941
2013
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Abstract
First described in 1998, Russell body gastritis is a rare chronic inflammatory condition characterized by abundant intramucosal polyclonal plasma cells, which contain intracytoplasmic eosinophilic globules of immunoglobulins (Russell bodies) that displace the nucleus, with an accompanying chronic inflammatory infiltrate. Russell bodies represent a cellular response to overstimulation of plasma cells, leading to the accumulation of abundant, nondegradable, condensed immunoglobulin in dilated rough endoplasmic reticulum cisternae. Russell body gastritis usually occurs in the gastric antrum, but two cases of Russell body duodenitis have been recently described. Herein, we report an unusual case of Barrett esophagus with prominent lymphoplasmacytic infiltration and Russell bodies, which expands the current spectrum of Russell body gastritis/duodenitis. Given the various anatomic locations in which Russell body gastritis may arise, we suggest that “Russell body gastroenteritis” may be a more appropriate designation for this uncommon reactive condition.
Reference Key
bhaijee2013caserussell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Feriyl Bhaijee, Keith A. Brown, Billy W. Long, Alexandra S. Brown
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Journal Frontiers in pharmacology
Year 2013
DOI
10.1155/2013/797264
URL
http://dx.doi.org/10.1155/2013/797264
Keywords
Medicine

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