nrp-1 gene expression in nasopharyngeal carcinoma tissue and regulating effect of targeted inhibition of gene expression on cell function
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ID: 210417
2016
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Abstract
Objective: To study NRP-1 gene expression in nasopharyngeal carcinoma tissue and
the regulating effect of targeted inhibition of gene expression on cell function. Methods:
Nasopharyngeal carcinoma tissue, adjacent tissue and normal tissue were collected, and
NRP-1 expression levels were detected; nasopharyngeal carcinoma CNE-2 cells were cultured
and transfected with NRP-1 siRNA and negative control (NC) siRNA, and the contents of
angiogenesis molecules, proliferation-related proteins and invasion-related proteins were
detected. Results: NRP-1 protein content, positive cell rate, staining intensity and IHC score in
nasopharyngeal carcinoma tissue were higher than those in adjacent tissue and normal tissue;
VEGF, bFGF, EGF and ANG-1 contents in culture medium of NRP1-siRNA group were lower
than those in NC-siRNA group; Tie-2, EGFR, Livin, Bmi-1, CDK6, CDK4, CCND1, E2F1,
LMP1, FN1, MT1-MMP and Fascin expression levels in cells of NRP1-siRNA group were
lower than those in NC-siRNA group. Conclusions: NRP-1 expression level significantly
increases in nasopharyngeal carcinoma tissue, and NRP-1 can promote nasopharyngeal
carcinoma angiogenesis, cell proliferation and invasion.
| Reference Key |
ma2016journalnrp-1
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|---|---|
| Authors | ;Xin-Ming Ma |
| Journal | journal of communications |
| Year | 2016 |
| DOI |
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