the therapeutic potential of propolis against damage caused by salmonella typhimurium in mice liver: a biochemical and histological study
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2015
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Abstract
Honeybee products are a rich source of nutritive supplements and traditional
medication. The increasing resistance of bacteria towards various antibiotics
and the limited scope of some vaccines makes it important to explore
alternative therapies to combat bacterial diseases. The present study aimed
to evaluate the antibacterial action of propolis using biochemical and
histopathological methods in Salmonella typhimurium-infected BALB/c mice.
Crude propolis was collected from an apiary and extracted with 70% ethanol.
Hepatotoxicity was induced in mice by infecting them with Salmonella
typhimurium (104 colony-forming units (CFU)), and the hepatoprotective
activity of propolis was evaluated by administration of different doses of
propolis (100, 300 and 500 mg/kg body weight) for 30 days. Biochemical and
histopathological examinations were performed at regular intervals during the
experimental period. Results obtained after treatment were compared with
similar studies performed on normal control mice. Infected mice showed
elevated liver marker enzymes and revealed the presence of characteristic
typhoidal nodules in histological preparations. These results point to the
therapeutic activity of propolis against Salmonella typhimurium.
| Reference Key |
preeti2015archivesthe
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|---|---|
| Authors | ;Kalia Preeti;Kumar Neelima R.;Harjai Kusum |
| Journal | gastrointestinal endoscopy |
| Year | 2015 |
| DOI |
10.2298/ABS141105040K
|
| URL | |
| Keywords |
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