polyunsaturated fatty acids for multiple sclerosis treatment

Clicks: 238
ID: 209415
2015
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Ranked #16 of 54 articles by views in american journal of transplantation : official journal of the american society of transplantation and the american society of transplant surgeons

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Abstract
INTRODUCTION Fatty acids have an important role in structure and function of the nervous system. Recently, epidemiologic studies on neurodegenerative disorders have evaluated the usefulness of polyunsaturated fatty acids on multiple sclerosis. OBJECTIVE To examine recent studies, clinical trials, and reviews on the therapeutic effect of polyunsaturated fatty acids in multiple sclerosis. METHODS We conducted a search in MEDLINE/PubMed and Cochrane Library with the terms "fatty acids", "omega-3" and "omega-6" in combination with "multiple sclerosis". Articles were selected according to their relevance on the topic. RESULTS Epidemiologic studies have shown benefits of dietary supplementation with polyunsaturated fatty acids -especially omega-3- in relation to inflammatory, autoimmune and neurodegenerative disorders. In contrast, the studies do not show a beneficial effect of polyunsaturated fatty acids in multiple sclerosis. However, there are limitations related to design and sample issues in these studies CONCLUSIONS There is some evidence of a protective effect of polyunsaturated fatty acids on the risk of multiple sclerosis. Despite this, to date controlled trials have not produced definite results on the benefits of supplementation with polyunsaturated fatty acids in patients with multiple sclerosis. Any potential benefit will have to be confirmed in the long term.
Reference Key
kong-gonzlez2015medwavepolyunsaturated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Monserrat Kong-González;Jesús Giovanni Pérez-Cortéz;Carlos Hernández-Girón;Nayeli Macías-Morales;Mario Flores-Aldana
Journal american journal of transplantation : official journal of the american society of transplantation and the american society of transplant surgeons
Year 2015
DOI
10.5867/medwave.2015.01.6062
URL
http://www.medwave.cl/link.cgi/Medwave/Revisiones/RevisionClinica/6062
Keywords
pufa multiple sclerosis polyunsaturated fatty acids

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