4-hydroxy-nonenal—a bioactive lipid peroxidation product

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ID: 209026
2015
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Abstract
This review on recent research advances of the lipid peroxidation product 4-hydroxy-nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues, II. the diverse biochemical reactions with Michael adduct formation as the most prominent one, III. the endogenous targets of HNE, primarily peptides and proteins (here the mechanisms of covalent adduct formation are described and the (patho-) physiological consequences discussed), and IV. the metabolism of HNE leading to a great number of degradation products, some of which are excreted in urine and may serve as non-invasive biomarkers of oxidative stress.
Reference Key
schaur2015biomolecules4-hydroxy-nonenala Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rudolf J. Schaur;Werner Siems;Nikolaus Bresgen;Peter M. Eckl
Journal international journal of middle east studies
Year 2015
DOI
10.3390/biom5042247
URL
http://www.mdpi.com/2218-273X/5/4/2247
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