the role of micrornas in alzheimer’s disease and their therapeutic potentials

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ID: 209016
2018
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Abstract
MicroRNAs (miRNAs) are short, endogenous, non-coding RNAs that post-transcriptionally regulate gene expression by base pairing with mRNA targets. Altered miRNA expression profiles have been observed in several diseases, including neurodegeneration. Multiple studies have reported altered expressions of miRNAs in the brains of individuals with Alzheimer’s disease (AD) as compared to those of healthy elderly adults. Some of the miRNAs found to be dysregulated in AD have been reported to correlate with neuropathological changes, including plaque and tangle accumulation, as well as altered expressions of species that are known to be involved in AD pathology. To examine the potentially pathogenic functions of several dysregulated miRNAs in AD, we review the current literature with a focus on the activities of ten miRNAs in biological pathways involved in AD pathogenesis. Comprehensive understandings of the expression profiles and activities of these miRNAs will illuminate their roles as potential therapeutic targets in AD brain and may lead to the discovery of breakthrough treatment strategies for AD.
Reference Key
shaik2018genesthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Munvar Miya Shaik;Ian A. Tamargo;Murtala B. Abubakar;Mohammad A. Kamal;Nigel H. Greig;Siew Hua Gan
Journal thermal science and engineering progress
Year 2018
DOI
10.3390/genes9040174
URL
http://www.mdpi.com/2073-4425/9/4/174
Keywords
alzheimer’s disease mirnas

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