expression of cyclin d1 and ki-67 in endometrial hyperplasias and carcinomas
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ID: 208815
2008
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Abstract
Endometrioid and serous carcinomas of the endometrium differ dramatically in their pathogeny and clinical
behaviour. CyclinD1 is critical for the G1/S part of the cell cycle. Cyclin D1 is often overexpressed in human neoplasias,
by genes rearrangements, amplifications and mutations. Ki-67 is a cell proliferation marker that is positive in all phases of
the cell cycle except Go. The purpose of this study was to compare endometrial carcinomas with endometrial
hyperplasias, regarding their activity for cyclin D1 and Ki-67. Immunostains with Ki-67 and cyclin D1 antibodies were
performed on formalin-fixed and paraffin-embedded tissue sections from 15 cases: 10 endometrial carcinomas,
endometrioid and serous papillary, and 5 simple and complex hyperplasias, with and without cytologic atypia. Ki-67 was
positive in all proliferative and neoplastic endometria. It is emphasized that the association of the cyclin D1 expression
with the clinical aggressiveness is possible, but insufficient proved by now. Overexpression of cyclin D1 increases from
normal endometrium to hyperplasia and carcinoma, suggesting that it may play a role in endometrial carcinogenesis.
| Reference Key |
balan2008analeleexpression
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| Authors | ;Raluca Balan;Cornelia Amalinei;Eduard Crauciuc;Draga-Irina Caruntu;Vlad Gheorghita;Ovidiu Toma |
| Journal | international journal of online engineering (ijoe) |
| Year | 2008 |
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