the role of activator protein-1 (ap-1) family members in cd30-positive lymphomas

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ID: 208671
2018
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Abstract
The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analysed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in diverse transcriptional response profiles. However, as a result of the increasing knowledge of the role of AP-1 TFs in disease, these TFs are being recognized as promising therapeutic targets for various malignancies. In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma.
Reference Key
alonso2018cancersthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ines Garces de los Fayos Alonso;Huan-Chang Liang;Suzanne D. Turner;Sabine Lagger;Olaf Merkel;Lukas Kenner
Journal The Journal of investigative dermatology
Year 2018
DOI
10.3390/cancers10040093
URL
http://www.mdpi.com/2072-6694/10/4/93
Keywords
Oncology including cancer and carcinogens tumors

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