oral toxicity of okadaic acid in mice: study of lethality, organ damage, distribution and effects on detoxifying gene expression

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ID: 208487
2013
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Abstract
In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach. Because several reports differ in the damage detected in different organs, and on okadaic acid distribution after consumption, we determined the toxicity of this compound after oral administration to mice. After 24 hours, histopathological examination showed necrotic foci and lipid vacuoles in the livers of intoxicated animals. By immunohistochemical analysis, we detected this toxin in the liver and kidneys of intoxicated animals. Okadaic acid induces oxidative stress and can be activated in vitro into reactive compounds by the post-mitochondrial S9 fraction, so we studied the okadaic effect on the gene expression of antioxidant and phase II detoxifying enzymes in liver. We observed a downregulation in the expression of these enzymes and a reduction of protein expression of catalase and superoxide dismutase 1 in intoxicated animals.
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botana2013toxinsoral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Luis M. Botana;Félix V. Vega;Mercedes R. Vieytes;Paz Otero;José Manuel Cifuentes;Roberto Bermúdez;Amparo Alfonso;Henar López-Alonso;Andres C. Vieira;Juan A. Rubiolo
Journal matec web of conferences
Year 2013
DOI
10.3390/toxins5112093
URL
http://www.mdpi.com/2072-6651/5/11/2093
Keywords
diarrhea quantitative pcr histopathology liver immunohistochemistry catalase okadaic acid micemedicine superoxide dismutase 1

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