an overview of biomarkers and molecular signatures in hcc

Clicks: 120
ID: 208292
2010
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Abstract
Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Although most HCCs seem to originate from the accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear. Long-term survival of HCC patients is also poor, partly due to HCC recurrence. Although serum alpha-fetoprotein (AFP) level is a useful marker for the detection and monitoring of HCC, AFP levels may remain normal in the patients even with advanced HCC. To identify useful biomarkers for HCC, many studies have been conducted on molecular events such as genetic and epigenetic alterations, and gene expression. This review summarizes recent studies of potential molecular markers for diagnosis and monitoring metastasis or recurrence of HCC.
Reference Key
yim2010cancersan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Seon-Hee Yim;Yeun-Jun Chung
Journal The Journal of investigative dermatology
Year 2010
DOI
10.3390/cancers2020809
URL
http://www.mdpi.com/2072-6694/2/2/809/
Keywords
Biomarker hepatocellular carcinoma Oncology including cancer and carcinogens tumors

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