in vitro chemoprotective and anticancer activities of propolis in human lymphocytes and breast cancer cells
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ID: 207436
2015
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Abstract
Propolis has been used in folk medicine for centuries due to its healing
properties. Ethanolic extracts of propolis (EEP) are rich sources of phenolic
acid and flavonoids. Natural phenolic compounds may exert chemoprotective
activity in cancer cells due to their ability to scavenge free radicals. The
aim of this in vitro study was to investigate the genotoxic and
anti-mutagenic effects of the EEP on human peripheral blood lymphocytes
(PBLs) and their cytotoxic potential on the human breast cancer cell line
(MDA-MB-231 cells). Both cell cultures were treated with six concentrations
(1, 10, 50, 100, 250 and 500 μg/ml) of EEP1 and EEP2, separately and in
combination with mitomycin C (MMC). Our results show that the EEP1 and EEP2
samples of propolis after separate and combined treatments with MMC did not
influence the nuclear division index (NDI). In the combined treatment, both
tested EEPs significantly reduced MMC-induced micronuclei (MN) in PBLs. At 48
h after exposure of the MDA-MB-231 cell line to a combined treatment of EEP
samples with MMC, the IC50 values were significantly reduced (23.79 and 19.13
μg/ml, for EEP1+MMC and EEP2+MMC, respectively, in comparison to the single
treatment. In conclusion, the tested ethanolic extracts of propolis exhibited
a certain level of in vitro antimutagenic activity in PBLs from healthy
subjects, and anticancer activity in breast cancer cell line. The presented
findings suggest that the ethanolic extracts of propolis show potential in
anticancer therapeutic strategy. [Projekat Ministarstva nauke Republike
Srbije, br. III41010]
| Reference Key |
olivera2015archivesin
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|---|---|
| Authors | ;Milošević-Đorđević Olivera;Grujičić Darko;Radović Marina;Vuković Nenad;Žižić Jovana;Marković Snežana |
| Journal | gastrointestinal endoscopy |
| Year | 2015 |
| DOI |
10.2298/ABS141013019M
|
| URL | |
| Keywords |
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