Dehydrative Transformation of Spirooxindoles to Pyrido[2,3-]indoles via POCl.

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ID: 20728
2019
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Abstract
A two-step one-pot efficient synthesis of pyrido[2,3-]indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. The initial 1,3-dipolar cycloaddition between the reactants that is performed in the presence of either CuI or methanol results in spirooxindoles that undergo POCl-mediated intramolecular dehydrative transformation to afford the title compounds.
Reference Key
kolle2019dehydrativeacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kolle, Shivalinga;Barak, Dinesh S;Ghosh, Aritra;Jaiswal, Vandana;Kant, Ruchir;Batra, Sanjay;
Journal ACS omega
Year 2019
DOI
10.1021/acsomega.9b00396
URL
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