antimycobacterial natural products from moroccan medicinal plants: chemical composition, bacteriostatic and bactericidal profile of thymus satureioides and mentha pulegium essential oils

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ID: 206983
2016
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Abstract
Objective: To evaluate the susceptibility of Mycobacterium aurum and Mycobacterium smegmatis in vitro to the essential oils obtained from two medicinal plants: Thymus satureioides (T. satureioides) and Mentha pulegium (M. pulegium), and to study their chemical composition. Methods: The aerial parts of T. satureioides and M. pulegium (leaves and stems) were hydro-distillated using a Clevenger-type apparatus and essential oils were analyzed and identified by gas chromatography-mass spectrometry. Antimycobacterial screening of essential oils was performed on the basis of the inhibition zone diameter by disc diffusion method against two mycobacterial strains whereas the minimal inhibitory concentration and minimal bactericidal concentration were determined by using the micro-dilution method. Results: Chemical analysis of their aerial part's essential oils gave as major compounds, borneol (34.26%), carvacrol (31.21%) and thymol (3.71%) for T. satureioides and R(+)-pulegone (75.48%), carvone (6.66%) and dihydrocarvone (4.64%) for M. pulegium. Thereafter their antimycobacterial effect evaluation, using the micro-dilution method, indicated that minimal inhibitory concentration values of T. satureioides essential oil ranged from 0.062% to 0.015% (v/v) and from 0.125% to 0.031% (v/v) for M. pulegium respectively against Mycobacterium aurum and Mycobacterium smegmatis. Conclusions: It is clearly evident from the results obtained that the Moroccan medicinal plants have great potential to be used as anti-tuberculosis agents. These findings may help scientists to undertake several research projects to discover useful natural product as new anti-tuberculosis drug.
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chraibi2016asianantimycobacterial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marwa Chraibi;Abdellah Farah;Sara Lebrazi;Oumaima El Amine;Mohammed Iraqui Houssaini;Kawtar Fikri-Benbrahim
Journal Organic letters
Year 2016
DOI
10.1016/j.apjtb.2016.08.002
URL
http://www.sciencedirect.com/science/article/pii/S2221169115309473
Keywords
Chemical composition Essential oil mentha pulegium tropical medicinebiology (general) antimycobacterial activityarctic medicine

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