maculopatia tóxica por antimaláricos: detecção pela tomografia óptica espectral de alta resolução: relato de casos toxic maculopathy caused by antimalarial drugs: detection using spectral domain oct: case reports

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ID: 206879
2009
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Abstract
As drogas antimaláricas, como a cloroquina, são úteis no controle de doenças reumáticas, mas podem causar lesões oculares potencialmente graves como a retinopatia cloroquínica (RC). Neste relato, são descritos os achados à tomografia de coerência óptica convencional e na espectral de alta resolução (HD-OCT) em aparelho CirrusTM HD-OCT de duas pacientes com RC. Em um dos casos, chama a atenção à similaridade entre a imagem de atrofia do epitélio pigmentado retiniano (EPR) na angiofluoresceinografia e a obtida na HD-OCT por segmentação "en -face" (reconstruções coronais). Em outra paciente, com sinais clínicos de maculopatia, mas sem anormalidades na angiofluoresceinografia, os sinais de atrofia do EPR foram também observados nos "scans" da HD-OCT, levantando a possibilidade de que esta técnica possa permitir a detecção precoce desta doença.
Antimalarial drugs, such as chloroquine, are useful in the management of rheumatic diseases, but may cause a potentially blinding condition known as toxic maculopathy. This report describes the findings on standard and on high-resolution spectral domain ocular coherence tomography performed in a CirrusTM HD-OCTdevice in two patients with chloroquine maculopathy. In one case, a very similar aspect of retinal pigment epithelium (RPE) plaque atrophy occured in both angiographic and HD-OCT images obtained by "en-face" (coronal) segmentation. In another patient with clinical signs of maculopathy and no angiographic abnormalities, signs of RPE atrophy could also be observed in HD-OCT scans, raising the possibility that this technique may allow the early detection of the disease.
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neto2009arquivosmaculopatia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Laurentino Biccas Neto;Arthur Silva de Mesquita
Journal introducing innodb cluster: learning the mysql high availability stack
Year 2009
DOI
10.1590/S0004-27492009000500023
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000500023
Keywords
tomography retinal disease chloroquine Optical Coherence case reportsophthalmology

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