minimal impairment in a rat model of duration discrimination following excitotoxic lesions of primary auditory and prefrontal cortices

Clicks: 378
ID: 206244
2011
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #6 of 133 articles by views in Vacuum

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 133 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
We present a behavioral paradigm for the study of duration perception in the rat, and report the result of neurotoxic lesions that have the goal of identifying sites that mediate duration perception. Using a two-alternative forced-choice paradigm, rats were either trained to discriminate durations of pure tones (range=[200,500]ms; boundary=316ms; Weber fraction after training=0.24+/-0.04), or were trained to discriminate frequencies of pure tones (range=[8,16]kHz; boundary=11.3kHz; Weber=0.16+/-0.11); the latter task is a control for non-timing-specific aspects of the former. Both groups discriminate the same class of sensory stimuli, use the same motions to indicate decisions, have identical trial structures, and are trained to psychophysical threshold; the tasks are thus matched in a number of sensorimotor and cognitive demands. We made neurotoxic lesions of candidate timing-perception areas in the cerebral cortex of both groups. Following extensive bilateral lesions of the auditory cortex, the performance of the frequency-discrimination group was significantly more impaired than that of the duration-discrimination group. We also found that extensive bilateral lesions of the medial prefrontal cortex resulted in little to no impairment of both groups. The behavioral framework presented here provides an audition-based approach to study the neural mechanisms of time estimation and memory for durations.
Reference Key
pai2011frontiersminimal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Shraddha S Pai;Shraddha S Pai;Jeffrey C Erlich;Jeffrey C Erlich;Charles eKopec;Charles eKopec;Carlos D Brody;Carlos D Brody
Journal Vacuum
Year 2011
DOI
10.3389/fnsys.2011.00074
URL
http://journal.frontiersin.org/Journal/10.3389/fnsys.2011.00074/full
Keywords
perception cognition timing auditory cortex animal behavior neuropsychiatry biological psychiatry auditionneurosciences

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.