cytokine profiles of severe influenza virus-related complications in children

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ID: 206045
2017
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Abstract
RationaleEffective immunomodulatory therapies for children with life-threatening “cytokine storm” triggered by acute influenza infection are lacking. Understanding the immune profiles of children progressing to severe lung injury and/or septic shock could provide insight into pathogenesis.ObjectivesTo compare the endotracheal and serum cytokine profiles of children with influenza-related critical illness and to identify their associations with severe influenza-associated complications.MethodsChildren with influenza-related critical illness were enrolled across 32 hospitals in development (N = 171) and validation (N = 73) cohorts (December 2008 through May 2016). Concentrations of 42 cytokines were measured in serum and endotracheal samples and clustered into modules of covarying cytokines. Relative concentrations of cytokines and cytokine modules were tested for associations with acute lung injury (ALI), shock requiring vasopressors, and death/ECMO.Measurements and main resultsModules of covarying cytokines were more significantly associated with disease severity than individual cytokines. In the development cohort, increased levels of a serum module containing IL6, IL8, IL10, IP10, GCSF, MCP1, and MIP1α [shock odds ratio (OR) = 3.37, family-wise error rate (FWER) p < 10−4], and decreased levels of a module containing EGF, FGF2, SCD40L, and PAI-1 (shock OR = 0.43, FWER p = 0.002), were both associated with ALI, shock, and death-ECMO independent of age and bacterial coinfection. Both of these associations were confirmed in the validation cohort. Endotracheal and serum cytokine associations differed markedly and were differentially associated with clinical outcomes.ConclusionWe identified strong positive and negative associations of cytokine modules with the most severe influenza-related complications in children, providing new insights into the pathogenesis of influenza-related critical illness in children. Effective therapies may need to target mediators of both inflammation and repair.
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Authors ;Andrew Fiore-Gartland;Angela Panoskaltsis-Mortari;Anna A. Agan;Anushay J. Mistry;Paul G. Thomas;Michael A. Matthay;Michael A. Matthay;PALISI PICFlu Investigators;Tomer Hertz;Tomer Hertz;Tomer Hertz;Adrienne G. Randolph;Adrienne G. Randolph;Adrienne G. Randolph;Ronald C. Sanders;Glenda Hefley;David Tellez;Courtney Bliss;Aimee Labell;Danielle Liss;Ashley L. Ortiz;Katri Typpo;Jen Deschenes;Barry Markovitz;Jeff Terry;Rica Sharon P. Morzov;Ana Lia Graciano;Melita Baldwin;Nick Anas;Adam Schwarz;Chisom Onwunyi;Stephanie Osborne;Tiffany Patterson;Ofelia Vargas-Shiraishi;Anil Sapru;Maureen Convery;Victoria Lo;Heidi Flori;Becky Brumfield;Julie Simon;Angela Czaja;Peter Mourani;Valeri Batara Aymami;Susanna Burr;Megan Brocato;Stephanie Huston;Emily Jewett;Danielle Loyola;Christopher Carroll;Kathleen Sala;Sherell Thornton-Thompson;John S. Giuliano;Joana Tala;Gwenn McLaughlin;Matthew Paden;Chee-Chee Manghram;Stephanie Meisner;Cheryl L. Stone;Juliane Bubeck Wardenburg;Andrea DeDent;Vicki Montgomery;Janice Sullivan;Tracy Evans;Kara Richardson;Melissa Thomas;Adrienne Randolph;Anna A. Agan;Anushay J. Mistry;Ryan M. Sullivan;Stephanie Cobb;Melania Bembea;Elizabeth D. White;Stephen Kurachek;Angela A. Doucette;Erin Olson;Mary Hartman;Rachel Jacobs;Edward Truemper;Machelle Dawson;Daniel L. Levin;J. Dean Jarvis;Chhavi Katyal;Kate Ackerman;L. Eugene Daugherty;Laurel Baglia;Mark W. Hall;Kristin Greathouse;Lisa Steele;Neal Thomas;Jill Raymond;Debra Spear;Julie Fitzgerald;Mark Helfaer;Scott Weiss;Jenny L. Bush;Mary Ann Diliberto;Brooke B. Park;Martha Sisko;Frederick E. Barr;Renee Higgerson;LeeAnn Christie;Cindy Darnell;Shanda Johnson;Laura L. Loftis;Nancy Jaimon;Ursula Kyle;Rainer Gedeit;Briana E. Horn;Kate Luther;Kathy Murkowski;Douglas F. Willson;Robin L. Kelly;Philippe A. Jouvet;Anne-Marie Fontaine;Marc-André Dugas
Journal sudebno-meditsinskaia ekspertiza
Year 2017
DOI
10.3389/fimmu.2017.01423
URL
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01423/full
Keywords
cytokine influenza acute lung injury septic shock allergy inflammationimmunologic diseases

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