synchronous collagenous sprue and enteropathy-type t cell lymphoma: variants of the same disease
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ID: 205708
2004
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Abstract
A 64-year-old man with treated hypothyroidism had 10 months of diarrhea, abdominal pain, anorexia and recent involuntary 13.6 kg weight loss. He presented to hospital with an acute abdomen that had a radiological correlate of free air under the diaphragm. He was diagnosed with a perforated mid-jejunum due to an ulcerated enteropathy-type T cell lymphoma (ETL), complicating collagenous sprue and cryptic celiac disease. Polymerase chain reaction verified monoclonal g- and b-T cell receptor gene rearrangements in the neoplasm. He had a complete resolution of symptoms when treated with a gluten-free diet in the postoperative period. This is apparently the first report describing collagenous sprue and ETL as synchronous lesions. Because atypical CD8+ lymphocytes are in both the collagenous sprue epithelium and ETL, the implication is that collagenous sprue is a noninvasive component of the ETL.
| Reference Key |
medlicott2004canadiansynchronous
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|---|---|
| Authors | ;SAC Medlicott;PL Beck;S Loken;T Crabtree |
| Journal | indian journal of pharmacology |
| Year | 2004 |
| DOI |
10.1155/2004/583484
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| URL | |
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