ochratoxin a: 50 years of research

النقرات: 394
المعرّف: 205059
2016
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الملخص
Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings and animal health. For example, OTA can cause porcine nephropathy but can also damage poultries. Humans exposed to OTA can develop (notably by inhalation in the development of acute renal failure within 24 h) a range of chronic disorders such as upper urothelial carcinoma. OTA plays the main role in the pathogenesis of some renal diseases including Balkan endemic nephropathy, kidney tumors occurring in certain endemic regions of the Balkan Peninsula, and chronic interstitial nephropathy occurring in Northern African countries and likely in other parts of the world. OTA leads to DNA adduct formation, which is known for its genotoxicity and carcinogenicity. The present article discusses how renal carcinogenicity and nephrotoxicity cause both oxidative stress and direct genotoxicity. Careful analyses of the data show that OTA carcinogenic effects are due to combined direct and indirect mechanisms (e.g., genotoxicity, oxidative stress, epigenetic factors). Altogether this provides strong evidence that OTA carcinogenicity can also occur in humans.
المفتاح المرجعي
malir2016toxinsochratoxin استخدم هذا المفتاح للاستشهاد التلقائي في المخطوطة أثناء استخدام مدير المخطوطات أو مدير الأطروحات من SciMatic
المؤلفون ;Frantisek Malir;Vladimir Ostry;Annie Pfohl-Leszkowicz;Jan Malir;Jakub Toman
مجلة matec web of conferences
السنة 2016
DOI
10.3390/toxins8070191
URL
http://www.mdpi.com/2072-6651/8/7/191
الكلمات المفتاحية
toxicity feed ochratoxin a food carcinogenicity balkan endemic nephropathy

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