mitochondrial ferritin deletion exacerbates β-amyloid-induced neurotoxicity in mice
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2017
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Abstract
Mitochondrial ferritin (FtMt) is a mitochondrial iron storage protein which protects mitochondria from iron-induced oxidative damage. Our previous studies indicate that FtMt attenuates β-amyloid- and 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. To explore the protective effects of FtMt on β-amyloid-induced memory impairment and neuronal apoptosis and the mechanisms involved, 10-month-old wild-type and Ftmt knockout mice were infused intracerebroventricularly (ICV) with Aβ25–35 to establish an Alzheimer’s disease model. Knockout of Ftmt significantly exacerbated Aβ25–35-induced learning and memory impairment. The Bcl-2/Bax ratio in mouse hippocampi was decreased and the levels of cleaved caspase-3 and PARP were increased. The number of neuronal cells undergoing apoptosis in the hippocampus was also increased in Ftmt knockout mice. In addition, the levels of L-ferritin and FPN1 in the hippocampus were raised, and the expression of TfR1 was decreased. Increased MDA levels were also detected in Ftmt knockout mice treated with Aβ25–35. In conclusion, this study demonstrated that the neurological impairment induced by Aβ25–35 was exacerbated in Ftmt knockout mice and that this may relate to increased levels of oxidative stress.
| Reference Key |
wang2017oxidativemitochondrial
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|---|---|
| Authors | ;Peina Wang;Qiong Wu;Wenyue Wu;Haiyan Li;Yuetong Guo;Peng Yu;Guofen Gao;Zhenhua Shi;Baolu Zhao;Yan-Zhong Chang |
| Journal | journal of aoac international |
| Year | 2017 |
| DOI |
10.1155/2017/1020357
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| URL | |
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