induction of an antigen specific gut inflammatory reaction in mice and rats: a model for human inflammatory bowel disease

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ID: 204417
2009
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Abstract
Food allergy is an adverse reaction that occurs in susceptible people when they eat sensitizing foods and is one of the causes of Inflammatory Bowel Disease (IBD). The effort to understand the induction process of these diseases is important as IBD is increasing worldwide, including in Brazil. The aim of this study was to develop an experimental antigen specific inflammatory process of the gut of mice and rats, using peanut seeds. Animals were immunized with peanut protein extract before their exposure to the in natura peanut seeds. Results showed that systemic immunization with peanut protein extracts rendered significantly higher antibody titers than control groups and that immunized animals submitted to a challenge diet containing peanuts presented time dependent alterations of the gut similar to celiac disease. In conclusion, results suggested that this experimental model was a convenient tool to study the evolution of alterations in chronic antigen specific gut inflammatory process.
A alergia alimentar consiste em uma reação adversa que ocorre em pessoas susceptíveis quando ingerem alimentos sensibilizantes, sendo uma das causas das Doenças Inflamatórias Intestinais (IBD). O objetivo deste estudo foi desenvolver um protocolo experimental de indução de um processo inflamatório intestinal antígeno-específico em camundongos e ratos. Foi escolhida para a indução deste processo a semente de amendoim. Os animais foram imunizados com o extrato protéico previamente à exposição com a semente in natura. Nossos resultados mostram que a imunização sistêmica com extratos protéicos de amendoim ocasiona títulos significativamente maiores de anticorpos quando comparado ao grupo controle e que os animais imunizados submetidos ao desafio com a dieta contendo exclusivamente amendoim apresentam alterações intestinais tempo-dependente similares àquelas observadas na doença celíaca. Os resultados obtidos sugerem que este modelo experimental constitui uma ferramenta conveniente para avaliar as alterações no processo inflamatório intestinal crônico antígeno-específico
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Authors Gerlinde Agate Platais Brasil Teixeira, Danielle Mota Fontes Antunes, Archimedes Barbosa de Castro Júnior, Janilda Pacheco da Costa, Patrícia Olaya Paschoal, Sylvia Maria Nicolau Campos, Monique de Morais Bitetti Pedruzzi, Vinicius da Silva Araújo, Luis Antônio Botelho Andrade, Silvana Ramos Farias Moreno, Alberto Felix Antonio da Nobrega, Gilberto Perez Cardoso
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Journal current drug delivery
Year 2009
DOI
10.1590/S1516-89132009000300012
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000300012
Keywords
rats food allergy inflammatory bowel disease peanuts

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