evaluation of anti-inflammatory activity of solanum xanthocarpum schrad and wendl (kaṇṭakāri) extract in laboratory animals

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ID: 204391
2013
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Abstract
Context: Solanum xanthocarpum Schrad and Wendl (Kaṇṭakāri) is a diffuse herb with prickly stem, traditionally used for the treatment of inflammation and one in the group of daśamūla (group of ten herbs) herbs commonly used drug in Ayurveda. Aims: In continuation of search for potent natural anti-inflammatory agents, the present research work was planned to evaluate the anti-inflammatory activity of ethanol extract of S. xanthocarpum whole plant. Settings and Design: The ethanol extract was evaluated at dose 10, 30 and 100 mg/kg p.o. in rats. Materials and Methods: Using pharmacological screening models carrageenan induced rat paw edema, histamine induced rat paw edema and cotton pellet granuloma in rats. Statistical Analysis Used: Data obtained was analyzed statistically using analysis of variance followed by post-hoc Dunnett test, P < 0.05 is considered as statistically significant. Results: Acute treatment didn′t show anti-inflammatory activity against carrageenan and histamine induced paw edema. However, administration of 100 mg/kg p.o for 7 day reduced the granuloma formation in cotton pellet granuloma model. Conclusions: Present results support the traditional use of plant for anti-inflammatory activity. In brief, the results provide scientific pharmacological basis for the therapeutic use of S. xanthocarpum.
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Authors ;Shraddha K More;Anirudha A Lande;Priti G Jagdale;Prafulla P Adkar;Shirishkumar D Ambavade
Journal Clinical chemistry and laboratory medicine
Year 2013
DOI
10.4103/0257-7941.131976
URL
http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2013;volume=32;issue=4;spage=222;epage=226;aulast=More
Keywords
histamine anti-inflammatory carrageenan

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