effects of helicobacter pylori water extract on expression of endothelial adhesion molecules
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ID: 203666
2004
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Abstract
The present study investigated whether Helicobacter pylori water extract induces the upregulation of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin on human umbilical vein endothelial cells, using an ELISA. The nature of the substances mediating this upregulation was also analyzed. H pylori water extract derived from type strain (NCTC 11637) significantly upregulated intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin to the same extent as interleukin-1. Treatments with extracts from clinical strains showed no significant increases in expression of these adhesion molecules. In a fractionation study, approximately 7 kDa fraction showed peak activity. This activity was tolerant to heating and trypsin digestion. These results indicate that H pylori water extract contains water-soluble, low-molecular, nonprotein substances which induce upregulation of adhesion molecules on human umbilical vein endothelial cells, suggesting that products of H pylori may elicit gastric mucosal inflammation by promoting expression of endothelial adhesion molecules.
| Reference Key |
yoshida2004canadianeffects
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|---|---|
| Authors | ;Norimasa Yoshida;Kyoichi Kassai;Hironobu Murase;Yukiko Tanaka;Satoshi Kokura;Hiroshi Ichikawa;Yuji Naito;Takeshi Okanoue;Toshikazu Yoshikawa |
| Journal | indian journal of pharmacology |
| Year | 2004 |
| DOI |
10.1155/2004/158638
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| URL | |
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